Article
Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma.
Human molecular genetics - 15 Oct 2011
Burnichon Nelly, Vescovo Laure, Amar Laurence, Libé Rossella, de Reynies Aurélien, Venisse Annabelle, Jouanno Elodie, Laurendeau Ingrid, Parfait Béatrice, Bertherat Jérôme, Plouin Pierre-François, Jeunemaitre Xavier, Favier Judith, Gimenez-Roqueplo Anne-Paule
Abstract excerpt
Pheochromocytomas and paragangliomas are neuroendocrine tumors that occur in the context of inherited cancer syndromes in ∼30% of cases and are linked to germline mutations in the VHL, RET, NF1, SDHA, SDHB, SDHC, SDHD, SDHAF2 and TMEM127 genes. Although genome-wide expression studies have revealed some of the mechanisms likely to be involved in pheochromocytoma/paraganglioma tumorigenesis, the complete molecular...
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