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Article

ATRX driver mutation in a composite malignant pheochromocytoma.

Cancer genetics - 1 Jun 2016

Comino-Méndez Iñaki, Tejera Águeda M, Currás-Freixes María, Remacha Laura, Gonzalvo Pablo, Tonda Raúl, Letón Rocío, Blasco María A, Robledo Mercedes, Cascón Alberto

Abstract excerpt

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. Approximately 40% of PCCs/PGLs are due to germline mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in 5 main genes. Recently, somatic ATRX mutations have been found in succinate dehydrogenase (SDH)-associated...

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Identifiers

PMID: 27209355
DOI: 10.1016/j.cancergen.2016.04.058

Genes

ATRX

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