Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles.

doi:10.1038/s41467-025-57595-y

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Article

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles.

Nature communications - 17 Mar 2025

Flynn Aidan, Pattison Andrew D, Balachander Shiva, Boehm Emma, Bowen Blake, Dwight Trisha, Rossello Fernando J, Hofmann Oliver, Martelotto Luciano, Zethoven Maia, Kirschner Lawrence S, Else Tobias, Fishbein Lauren, Gill Anthony J, Tischler Arthur S, Giordano Thomas, Prodanov Tamara, Noble Jane R, Reddel Roger R, Trainer Alison H, Ghayee Hans Kumar, Bourdeau Isabelle, Elston Marianne, Ishak Diana, Ngeow Yuen Yie Joanne, Hicks Rodney J, Crona Joakim, Åkerström Tobias, Stålberg Peter, Dahia Patricia, Grimmond Sean, Clifton-Bligh Roderick, Pacak Karel, Tothill Richard W

Abstract excerpt

Hereditary SDHB-mutant pheochromocytomas (PC) and paragangliomas (PG) are rare tumours with a high propensity to metastasize although their clinical behaviour is unpredictable. To characterize the genomic landscape of these tumours and identify metastasis biomarkers, we perform multi-omic analysis on 94 tumours from 79 patients using seven molecular methods. Sympathetic (chromaffin cell) and parasympathetic...

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Identifiers

PMID: 40097403
DOI: 10.1038/s41467-025-57595-y
PMCID: PMC11914184

Genes

SDHB
ATRX
EPAS1
MGMT
PC
TERT

Provenance

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