Article
Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing.
The Journal of clinical endocrinology and metabolism - 1 Jul 2013
Crona Joakim, Delgado Verdugo Alberto, Maharjan Rajani, Stålberg Peter, Granberg Dan, Hellman Per, Björklund Peyman
Abstract excerpt
CONTEXT: Up to 60% of pheochromocytoma (PCC) and paraganglioma (PGL) are associated with either somatic or germline mutations in established PCC and PGL susceptibility loci. Most unexplained cases are characterized by an increased activity of the RAS/RAF/ERK signaling pathway. Mutations in RAS su...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.