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Article

INSIG1 influences obesity-related hypertriglyceridemia in humans.

Journal of lipid research - 1 Apr 2010

Smith E M, Zhang Y, Baye T M, Gawrieh S, Cole R, Blangero J, Carless M A, Curran J E, Dyer T D, Abraham L J, Moses E K, Kissebah A H, Martin L J, Olivier M

Abstract excerpt

In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the region. Insulin-induced genes (INSIGs) are feedback mediators of cholesterol and fatty acid synthesis in animals, but their role in human lipid regulation is unclear....

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Source

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Identifiers

PMID: 19965593
DOI: 10.1194/jlr.M001404
PMCID: PMC2838707

Genes

INSIG1
INSIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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INSIG1 influences obesity-related hypertriglyceridemia in humans.PMID 19965593Read ↗

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