Article
The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets.
Scientific reports - 9 Dec 2020
Murayama Ayako Y, Kuwako Ken-Ichiro, Okahara Junko, Bae Byoung-Il, Okuno Misako, Mashiko Hiromi, Shimogori Tomomi, Walsh Christopher A, Sasaki Erika, Okano Hideyuki
Abstract excerpt
GPR56, a member of the adhesion G protein-coupled receptor family, is abundantly expressed in cells of the developing cerebral cortex, including neural progenitor cells and developing neurons. The human GPR56 gene has multiple presumptive promoters that drive the expression of the GPR56 protein in distinct patterns. Similar to coding mutations of the human GPR56 gene that may cause GPR56 dysfunction, a 15-bp...
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