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Article

GPR56 functions together with α3β1 integrin in regulating cerebral cortical development.

PloS one - 1 Jan 2013

Jeong Sung-Jin, Luo Rong, Singer Kathleen, Giera Stefanie, Kreidberg Jordan, Kiyozumi Daiji, Shimono Chisei, Sekiguchi Kiyotoshi, Piao Xianhua

Abstract excerpt

Loss of function mutations in GPR56, which encodes a G protein-coupled receptor, cause a specific human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Studies from BFPP postmortem brain tissue and Gpr56 knockout mice have previously showed that GPR56 deletion leads to breaches in the pial basement membrane (BM) and neuronal ectopias during cerebral cortical development. Since α3β1...

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Identifiers

PMID: 23874761
DOI: 10.1371/journal.pone.0068781
PMCID: PMC3706371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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