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Article

A Thermonuclease of <i>Neisseria gonorrhoeae</i> Enhances Bacterial Escape From Killing by Neutrophil Extracellular Traps

20 Jan 2015

Abstract excerpt

Acute gonorrhea is characterized by neutrophilic inflammation that is insufficient to clear Neisseria gonorrhoeae. Activated neutrophils release extracellular traps (NETs), which are composed of chromatin and decorated with antimicrobial proteins. The N. gonorrhoeae NG0969 open reading frame contains a gene (nuc) that encodes a putatively secreted thermonuclease (Nuc) that contributes to biofilm remodeling. Here,...

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PMID: 25605868
DOI: 10.1093/infdis/jiv031

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