Article
Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth.
Microbiology (Reading, England) - 1 Apr 2015
de Buhr Nicole, Stehr Matthias, Neumann Ariane, Naim Hassan Y, Valentin-Weigand Peter, von Köckritz-Blickwede Maren, Baums Christoph G
Abstract excerpt
The porcine and human pathogen Streptococcus suis induces and degrades neutrophil extracellular traps (NETs) in vitro. In this study, we investigated the working hypothesis that NET degradation is mediated not only by the known secreted S. suis nuclease A (SsnA) but also by a so-far undescribed putative endonuclease A of S. suis (designated EndAsuis) homologous to the pneumococcal endonuclease A (EndA)....
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