Article

Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis

2024-09-24

Abstract excerpt

<title>Abstract</title> <p>Septic arthritis, primarily caused by <italic>Staphylococcus aureus</italic>, poses a significant risk of both mortality and morbidity due to its aggressive nature. The <italic>nuc1</italic>-encoded thermonuclease NucA of <italic>S. aureus</italic> degrades extracellular DNA/RNA, allowing the pathogen to escape neutrophil extracellular traps (NETs) and maintain the infection unabated. H...

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Literature Corpus work: 38bc8f36-2e98-5f9f-b1e5-1865abd0138f
DOI: 10.21203/rs.3.rs-4848416/v1

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