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Gentamicin induction of the gonococcal <i>hicAB</i> toxin-antitoxin encoding system and impact on gene expression influencing biofilm formation and in vivo fitness in a strain-specific manner

2025-06-11

Abstract excerpt

The continued emergence of Neisseria gonorrhoeae (Ng) isolates resistant to first-line antibiotics has focused efforts on understanding how alternative therapies such as expanded use of gentamicin (Gen) might counteract this global public health problem. Focusing on Gen as a viable alternative antibiotic for treatment of gonorrheal infections, we used RNA-Seq to determine if sub-lethal levels of Gen might impact...

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Literature Corpus work
511020ea-ca31-540f-9c14-ea8859ccf540
DOI
10.1101/2025.06.11.659166
Open publication

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Gentamicin induction of the gonococcal <i>hicAB</i> toxin-antitoxin encoding system and impact on gene expression influencing biofilm formation and in vivo fitness in a strain-specific mannerDOI 10.1101/2025.06.11.659166
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