Article
Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos.
Molecular biology and evolution - 1 May 2015
Teixeira João C, de Filippo Cesare, Weihmann Antje, Meneu Juan R, Racimo Fernando, Dannemann Michael, Nickel Birgit, Fischer Anne, Halbwax Michel, Andre Claudine, Atencia Rebeca, Meyer Matthias, Parra Genís, Pääbo Svante, Andrés Aida M
Abstract excerpt
Balancing selection maintains advantageous genetic and phenotypic diversity in populations. When selection acts for long evolutionary periods selected polymorphisms may survive species splits and segregate in present-day populations of different species. Here, we investigate the role of long-term balancing selection in the evolution of protein-coding sequences in the Homo-Pan clade. We sequenced the exome of 20...
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