Article
Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Su Meng, Yin Zhi-Hua, Wu Wei, Li Xue-Lian, Zhou Bao-Sen
Abstract excerpt
BACKGROUND: The ataxia telangiectasia mutated (ATM) protein and p53 play key roles in sensing and repairing radiation-induced DNA double strand breaks (DSBs). Accumulating epidemiological evidence indicates that functional genetic variants in ATM and TP53 genes may have an impact on the risk of radiotherapy-induced side effects. Here we performed a meta-analysis to investigate the potential interaction between...
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