Article
Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese.
Journal of cancer research and clinical oncology - 1 Sept 2015
Ge Jie, Zhu Lin, Zhou Junde, Li Guangxiao, Li Ye, Li Shuying, Wu Zhiwei, Rong Jiesheng, Yuan Huiping, Liu Yanhong, Chi Qiang, Piao Daxun, Zhao Yashuang, Cui Binbin
Abstract excerpt
PURPOSE: T lymphocyte immune responses are controlled by both co-stimulatory and co-inhibitory signaling through T cell co-receptors. Cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death 1 (PD-1) and B and T lymphocyte attenuator (BTLA) are all co-inhibitory molecules that negatively regulate the activation of T cells. In this study, we investigated the relationship between ten tagging SNPs in three...
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