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Polymorphisms in genes involved in the mechanism of action of methotrexate: are they associated with outcome in rheumatoid arthritis patients?

Pharmacogenomics - 1 Jun 2014

Salazar Juliana, Moya Patricia, Altés Albert, Díaz-Torné César, Casademont Jordi, Cerdà-Gabaroi Dacia, Corominas Hèctor, Baiget Montserrat

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is the first-line treatment option for newly diagnosed rheumatoid arthritis (RA) patients. However, 50-70% of the patients respond to treatment and 30% suffer toxicity. AIM: To identify pharmacogenetic markers of outcome in RA patients treated with MTX. PATIENTS & METHODS: We analyzed 27 genetic variants in DHFR, TYMS, MTHFR, ATIC and CCND1 genes. RESULTS: We included 124 RA...

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Source

Identifiers

PMID: 25084201
DOI: 10.2217/pgs.14.67

Genes

ATIC
DHFR
MTHFR
CCND1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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