Article
Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.
Genetic testing and molecular biomarkers - 1 May 2017
Shao Wenjing, Yuan Yi, Li Yuying
Abstract excerpt
PURPOSE: Methotrexate (MTX) is one of the most widely used disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis (RA). However, its efficacy in RA patients is variable and unpredictable. Methylene tetrahydrofolate reductase (MTHFR) is an important enzyme in the MTX pathway and is involved in folate metabolism and DNA synthesis. Several studies have examined the association between the...
Topics
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Asian People
- Female
- Folic Acid
- Genotype
- Humans
- Male
- Methotrexate
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Single Nucleotide
- Treatment Outcome
- White People