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Article

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.

Breast cancer research : BCR - 8 Sept 2017

Williams Michelle M, Vaught David B, Joly Meghan Morrison, Hicks Donna J, Sanchez Violeta, Owens Philip, Rahman Bushra, Elion David L, Balko Justin M, Cook Rebecca S

Abstract excerpt

BACKGROUND: During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine kinase ErbB4 is required for STAT5A activation in MECs during pregnancy, it is unclear how ErbB3, a heterodimeric partner of ErbB4 and activator...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28886748
DOI: 10.1186/s13058-017-0893-7
PMCID: PMC5591538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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