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Article

Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.

Oncogene - 12 Dec 2002

Zhou Hang, Liu Lili, Lee Keunmyoung, Qin Xiusheng, Grasso Adam W, Kung Hsing-Jien, Willis Joesph E, Kern Jeffery, Wagner Thomas, Gerson Stanton L

Abstract excerpt

Erb-B-3 overexpression is associated with poor prognosis in non-small cell lung cancer and is often overexpressed in breast cancers. MMTVhuman-erb-B-3 transgenic mice were generated to evaluate the impact of erb-B-3 overexpression on lung and mammary gland tumorigenesis. These transgenic mice developed a high incidence of lung adenocarcinomas but not mammary gland tumors. The tumors overexpressed transgenic human...

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PMID: 12483526
DOI: 10.1038/sj.onc.1205984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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