Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence.

doi:10.1037/a0023871

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Article

Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence.

Developmental psychology - 1 Jul 2011

Cole Steven W, Arevalo Jesusa M G, Manu Kavya, Telzer Eva H, Kiang Lisa, Bower Julienne E, Irwin Michael R, Fuligni Andrew J

Abstract excerpt

The authors tested the evolutionary genetic hypothesis that the functional form of an asymmetrically risky Gene × Environment interaction will differ as a function of age-related antagonistic pleiotropy (i.e., show opposite effects in young vs. old individuals). Previous studies have identified a polymorphism in the human IL6 promoter (rs1800795; IL6-74 G/C) that interacts with adverse socioenvironmental...

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PMID: 21639625
DOI: 10.1037/a0023871
PMCID: PMC3592928

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