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Article

Alcohol-induced ciliary dysfunction targets the outer dynein arm.

American journal of physiology. Lung cellular and molecular physiology - 15 Mar 2015

Yang Fan, Pavlik Jacqueline, Fox Laura, Scarbrough Chasity, Sale Winfield S, Sisson Joseph H, Wirschell Maureen

Abstract excerpt

Alcohol abuse results in an increased incidence of pulmonary infection, in part attributable to impaired mucociliary clearance. Analysis of motility in mammalian airway cilia has revealed that alcohol impacts the ciliary dynein motors by a mechanism involving altered axonemal protein phosphorylation. Given the highly conserved nature of cilia, it is likely that the mechanisms for alcohol-induced ciliary...

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Identifiers

PMID: 25595647
DOI: 10.1152/ajplung.00257.2014
PMCID: PMC4360061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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