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Article

Functional characterization of lethal P-loop mutations in Tetrahymena outer arm dynein (Dyh3p).

Biochemical and biophysical research communications - 19 Feb 2018

Edamatsu Masaki

Abstract excerpt

Mutational analyses of axonemal dyneins are useful for elucidating the molecular mechanism of ciliary motility. This study demonstrates a mutation system for characterizing lethal P-loop mutations in Tetrahymena outer arm dynein (Dyh3p). The viable DYH3-knockout (vKO-DYH3) cells isolated in this study enabled the examination of lethal mutations in P-loops 1 and 2. The P1 mutant dynein localized in the oral...

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PMID: 29425819
DOI: 10.1016/j.bbrc.2018.02.038

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