Article
An aurora kinase is essential for flagellar disassembly in Chlamydomonas.
Developmental cell - 1 Mar 2004
Pan Junmin, Wang Qian, Snell William J
Abstract excerpt
Cilia and flagella play key roles in development and sensory transduction, and several human disorders, including polycystic kidney disease, are associated with the failure to assemble cilia. Here, we show that the aurora protein kinase CALK in the biflagellated alga Chlamydomonas has a central role in two pathways for eliminating flagella. Cells rendered deficient in CALK were defective in regulated flagellar...
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