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Article

Reduced T-cell repertoire restrictions in abatacept-treated rheumatoid arthritis patients.

Journal of translational medicine - 16 Jan 2015

Imberti Luisa, Scarsi Mirko, Zanotti Cinzia, Chiarini Marco, Bertoli Diego, Tincani Angela, Airò Paolo

Abstract excerpt

BACKGROUND: CD28(neg) T cells, which display functional characteristic of oligoclonally expanded cytotoxic memory T lymphocytes, are believed to be pathologically relevant in rheumatoid arthritis manifestation. The CD28 co-stimulation blockade by abatacept can prevent the generation of CD28(neg) T-cell populations in these patients. METHODS: Samples were obtained before and after 12 months of abatacept therapy....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25592982
DOI: 10.1186/s12967-014-0363-2
PMCID: PMC4310138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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