Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance

25 Jan 2019

Abstract excerpt

Abstract Abatacept is a CTLA-4-Ig fusion protein that binds to the costimulatory ligands CD80 and CD86 and blocks their interaction with the CD28 and CTLA-4 receptors expressed by T cells, therefore inhibiting T cell activation and function. Abatacept has shown clinical efficacy in treating some autoimmune diseases but has failed to show clinical benefit in other autoimmune conditions. The reasons for these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30683697
DOI: 10.4049/jimmunol.1801425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and MaintenancePMID 30683697Read ↗

Costimulatory blockade depletes T peripheral helper, late-activated naïve, and DN2 B cells in rheumatoid arthritisSemantic proximity Read ↗

AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunitySemantic proximity Read ↗

Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunitySemantic proximity Read ↗

Biology and clinical relevance of follicular cytotoxic T cellsSemantic proximity Read ↗

Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritisSemantic proximity Read ↗

Reduced T-cell repertoire restrictions in abatacept-treated rheumatoid arthritis patients.Semantic proximity Read ↗

Mass cytometry identifies imbalance of multiple immune-cell subsets associated with biologics treatment in ankylosing spondylitis.Semantic proximity Read ↗

Treating autoimmune disease by targeting CD8+T suppressor cellsSemantic proximity Read ↗

TCF-7 differentially regulates CD4 T cells mediated alloimmunitySemantic proximity Read ↗

Clonally expanded CD38 <sup>hi</sup> cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritisSemantic proximity Read ↗

Genomic profiling of T cell activation reveals dependency of memory T cells on CD28 costimulationSemantic proximity Read ↗

Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic targetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.