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Article

Structural and regulatory elements of the interaction between amyloid-β protein precursor and Homer3.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Kyratzi Elli, Liakos Anastasios, Papadogiannaki Georgia, Efthimiopoulos Spiros

Abstract excerpt

Amyloid-β protein precursor (AβPP) metabolism and the accumulation of its derivative amyloid-β (Aβ) peptide in senile plaques have been considered key players in the development of Alzheimer's disease (AD). However, the mechanisms underlying the generation and the deposition of Aβ are not clear but emphasis has been given in the role of AβPP protein interactions that regulate its processing and offer a means to...

Topics

Amyloid beta-Protein Precursor
Analysis of Variance
Carrier Proteins
HEK293 Cells
Homer Scaffolding Proteins
Humans
Immunoprecipitation
Mutation
Phosphorylation
Protein Binding
Regulatory Elements, Transcriptional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25589726
DOI: 10.3233/JAD-141992

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