Article
Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.
Oncotarget - 28 Aug 2015
Jäger Wolfgang, Xue Hui, Hayashi Tetsutaro, Janssen Claudia, Awrey Shannon, Wyatt Alexander W, Anderson Shawn, Moskalev Igor, Haegert Anne, Alshalalfa Mohammed, Erho Nicholas, Davicioni Elai, Fazli Ladan, Li Estelle, Collins Colin, Wang Yuzhuo, Black Peter C
Abstract excerpt
Optimal animal models of muscle invasive bladder cancer (MIBC) are necessary to overcome the current lack of novel targeted therapies for this malignancy. Here we report on the establishment and characterization of patient-derived primary xenografts (PDX). Patient tumors were grafted under the renal capsule of mice and subsequently transplanted over multiple generations. Patient tumor and PDX were processed for...
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