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Article

A novel MC4R mutation associated with childhood-onset obesity: A case report

1 Dec 2014

Abstract excerpt

The melanocortin-4-receptor gene (MC4R) is a key regulator of energy homeostasis, food intake and body weight. MC4R gene mutations are associated with early-onset severe obesity. Most patients are heterozygotes, with some reports of homozygotes and compound heterozygotes. The authors report a case involving an eight-year-old girl with progressive weight gain from infancy, body mass index 44 kg/m(2) (>97th...

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PMID: 25587224
DOI: 10.1093/pch/19.10.515

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