Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of multiple drug resistance in HMEC-1 endothelial cells after long-term exposure to sunitinib

1 Dec 2014

Abstract excerpt

Multiple drug resistance is still an unsolved problem in cancer therapy. Our previous study demonstrated that the chemotherapeutic drug doxorubicin (Dox) induced upregulation of P-glycoprotein (P-gp) in endothelial cells, resulting in a 20-fold increase in drug resistance and reduced efficiency of Dox treatment in a mice tumor model. In this study, we exposed human microvascular endothelial cells (HMEC-1) to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Drug Transport and Resistance Mechanisms
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25587220
DOI: 10.2147/ott.s67251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Induction of multiple drug resistance in HMEC-1 endothelial cells after long-term exposure to sunitinibPMID 25587220Read ↗

Acquisition of drug resistance in endothelial cells by tumor-derived extracellular vesicles and cancer progressionSemantic proximity Read ↗

Activation of alternate prosurvival pathways accounts for acquired sunitinib resistance in U87MG glioma xenografts.Semantic proximity Read ↗

Inhibitor of vasculogenic mimicry restores sensitivity of resistant melanoma cells to DNA-damaging agents.Semantic proximity Read ↗

Enhancement of the loss of multiple drug resistance by hydroxyurea.Semantic proximity Read ↗

Multiple drug resistance phenotype of human endothelial cells induced by vascular endothelial growth factor 165.Semantic proximity Read ↗

Enhanced expression of the multidrug resistance gene in vindesine-resistant human esophageal cancer cells.Semantic proximity Read ↗

Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic ModificationsSemantic proximity Read ↗

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.Semantic proximity Read ↗

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistanceSemantic proximity Read ↗

Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.