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Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance

2019-05-31

Abstract excerpt

Resistance to systemic drug therapies is a major reason for the failure of anti-cancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapted to vincristine (UKF-NB-3 r VCR 1 ) and doxorubicin (UKF-NB-3 r DOX 20 ). Doxorubicin-loaded nanoparticles displayed increased anti-cancer activity in UKF-NB-3...

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Literature Corpus work
61b16bb6-bf08-5ef2-ad88-bf673d752bd8
DOI
10.1101/655662
Open publication

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