Article
Multiple drug resistance phenotype of human endothelial cells induced by vascular endothelial growth factor 165.
Acta pharmacologica Sinica - 1 Aug 2001
Zhang X S, Zhu X F, Gao J S, Qian C N, Kuang Z J, Liu Z C, Zeng Y X
Abstract excerpt
AIM: To investigate the effect of vascular endothelial growth factor 165 (VEGF165) on sensitivity of endothelial cells to anticancer drugs. METHODS: Human dermal microvessel endothelial cells (HDMEC) were incubated with anticancer drugs in the presence of VEGF165. Survival of endothelial cells was assayed by MTT method. DNA fragments of apoptosis were detected by agarose electrophoresis. Potential mechanisms...
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