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Acquisition of drug resistance in endothelial cells by tumor-derived extracellular vesicles and cancer progression

5 Jan 2024

Abstract excerpt

Angiogenesis by endothelial cells (ECs) is essential for tumor growth. Angiogenesis inhibitors are used in combination with anticancer drugs in many tumor types, but tumors eventually become resistant. Previously, the underlying mechanism for developing drug resistance was considered to be a change in the characteristics of tumor cells whereas ECs were thought to be genetically stable and do not contribute to...

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PMID: 38318528
DOI: 10.20517/cdr.2023.121

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