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Article

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.

Oncotarget - 30 Dec 2014

Xiang Lisha, Gilkes Daniele M, Hu Hongxia, Takano Naoharu, Luo Weibo, Lu Haiquan, Bullen John W, Samanta Debangshu, Liang Houjie, Semenza Gregg L

Abstract excerpt

Intratumoral hypoxia, which is associated with breast cancer metastasis and patient mortality, increases the percentage of breast cancer stem cells (BCSCs) but the underlying molecular mechanisms have not been delineated. Here we report that hypoxia-inducible factor 1 (HIF-1) triggers the expression and activity of TAZ, a transcriptional co-activator that is required for BCSC maintenance, through two discrete...

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Source

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Identifiers

PMID: 25587023
DOI: 10.18632/oncotarget.2997
PMCID: PMC4350363

Genes

SIAH1
LATS2
WWTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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