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Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency

12 Jan 2015

Abstract excerpt

STUDY QUESTION: Can the induced pluripotent stem cells (iPSCs) derived from women with primary ovarian insufficiency (POI) differentiate into germ cells for potential disease modeling in vitro? SUMMARY ANSWER: The iPSC lines derived from POI patients with 46, X, del(X)(q26) or 46, X, del(X)(q26)9qh+ could differentiate into germ cells and expressed lower levels of genes in the deletion region of the X chromosome....

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 25586786
DOI: 10.1093/humrep/deu358

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