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Differentiation of primordial germ cells from premature ovarian insufficiency-derived induced pluripotent stem cells

31 May 2019

Abstract excerpt

BACKGROUND: Premature ovarian insufficiency (POI) is a common disease in reproductive women. The pathogenesis of POI is not clear, although it is known that it involves the disorder of oocyte differentiation and development. The introduction of reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) offers a unique opportunity to study many aspects of POI from cell differentiation in vitro...

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PMID: 31151408
DOI: 10.1186/s13287-019-1261-6

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