Article
Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.
Cancer discovery - 1 Jul 2012
Koo Ghee Chong, Tan Soo Yong, Tang Tiffany, Poon Song Ling, Allen George E, Tan Leonard, Chong Soo Ching, Ong Whee Sze, Tay Kevin, Tao Miriam, Quek Richard, Loong Susan, Yeoh Kheng-Wei, Yap Swee Peng, Lee Kuo Ann, Lim Lay Cheng, Tan Daryl, Goh Christopher, Cutcutache Ioana, Yu Willie, Ng Cedric Chuan Young, Rajasegaran Vikneswari, Heng Hong Lee, Gan Anna, Ong Choon Kiat, Rozen Steve, Tan Patrick, Teh Bin Tean, Lim Soon Thye
Abstract excerpt
UNLABELLED: The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic-activating mutations (A572V and A573V) in 2 of 4 patients with NKTCLs. Further validation of the prevalence of JAK3 mutations was determined by Sanger sequencing and high-resolution melt (HRM) analysis in an additional 61 cases....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.