Article
Mutations in the signal transducer and activator of transcription family of genes in cancer.
Cancer science - 1 Apr 2018
Shahmarvand Nahid, Nagy Alexandra, Shahryari Jahanbanoo, Ohgami Robert S
Abstract excerpt
In recent years, it has become clear that members of the signal transducer and activator of transcription (STAT) family of genes play an important role in cancer. The STAT family consists of seven genes, STAT1-4, STAT5A, STAT5B and STAT6, that are involved in regulating cellular proliferation, apoptosis, angiogenesis and the immune system response. Constitutive activation of STAT3, via mutational changes, is...
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