Article
CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population.
Annals of human genetics - 1 Nov 2018
Pérez-Morales Rebeca, González-Zamora Alberto, González-Delgado María Fernanda, Calleros Rincón Esperanza Y, Olivas Calderón Edgar H, Martínez-Ramírez Ollin Celeste, Rubio Julieta
Abstract excerpt
BACKGROUND AND PURPOSE: Smoking is a major public health problem worldwide. Polymorphisms in CHRNA3, CHRNA5, and CHRNB4 receptors play a critical role in nicotine dependence, lung cancer (LC) risk, and chronic obstructive pulmonary disease (COPD). This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD....
Read the complete abstract on PubMed