Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bee venom processes human skin lipids for presentation by CD1a

12 Jan 2015

Abstract excerpt

Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms contain CD1-presented antigens. Here, we show that venoms activate human T cells via CD1a proteins. Whereas CD1 proteins typically present lipids, chromatographic separation of venoms unexpectedly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatology and Skin Diseases
Share to Healthcare and Venom Research
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25584012
DOI: 10.1084/jem.20141505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bee venom processes human skin lipids for presentation by CD1aPMID 25584012Read ↗

Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets.Semantic proximity Read ↗

Isolation and characterization of allergen-binding cells from normal and allergic donors.Semantic proximity Read ↗

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms.Semantic proximity Read ↗

Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A2.Semantic proximity Read ↗

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1dSemantic proximity Read ↗

Antigenic surface of the bee venom allergen phospholipase A2. Structural functional analysis of human IgG4 antibodies reveals potential role in protection.Semantic proximity Read ↗

Insect anaphylaxis: addressing clinical challenges.Semantic proximity Read ↗

Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes.Semantic proximity Read ↗

Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4.Semantic proximity Read ↗

CD1-Restricted T Cell Recognition of Microbial Lipoglycan AntigensSemantic proximity Read ↗

Secreted phospholipases A2, a new class of HIV inhibitors that block virus entry into host cellsSemantic proximity Read ↗

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approachesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.