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Article

Unraveling the degradation of artificial amide bonds in nylon oligomer hydrolase: from induced-fit to acylation processes.

Physical chemistry chemical physics : PCCP - 14 Feb 2015

Baba Takeshi, Boero Mauro, Kamiya Katsumasa, Ando Hiroyuki, Negoro Seiji, Nakano Masayoshi, Shigeta Yasuteru

Abstract excerpt

To elucidate how the nylon oligomer hydrolase (NylB) acquires its peculiar degradation activity towards non-biological amide bonds, we inspected the underlying enzymatic processes going from the induced-fit upon substrate binding to acylation. Specifically we investigated the mutational effects of two mutants, Y170F and D181G, indicated in former experiments as crucial systems because of their specific amino acid...

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PMID: 25581392
DOI: 10.1039/c4cp04419c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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