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Article

Automated Path Searching Reveals the Mechanism of Hydrolysis Enhancement by T4 Lysozyme Mutants.

International journal of molecular sciences - 23 Nov 2022

Xi Kun, Zhu Lizhe

Abstract excerpt

Bacteriophage T4 lysozyme (T4L) is a glycosidase that is widely applied as a natural antimicrobial agent in the food industry. Due to its wide applications and small size, T4L has been regarded as a model system for understanding protein dynamics and for large-scale protein engineering. Through structural insights from the single conformation of T4L, a series of mutations (L99A,G113A,R119P) have been introduced,...

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Identifiers

PMID: 36498954
DOI: 10.3390/ijms232314628
PMCID: PMC9736071

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