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Article

Dimer interface engineering significantly boosts the performance of organophosphate hydrolase for degrading methyl parathion.

International journal of biological macromolecules - 1 Apr 2026

Yang Qingru, Qu Zhi, Yu Linling, Sun Yan

Abstract excerpt

Multimeric enzymes are prevalent in nature and widely applied in industrial applications, so the stabilization of multimeric enzymes is of significance and practical value in enzyme engineering. Here, we proposed an energy-guided molecular dynamics (MD)-aided interface engineering (MDAIE) strategy aiming at enhancing the catalytic performance of a dimeric enzyme, organophosphate hydrolase (OPH), for degrading...

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Identifiers

PMID: 41933771
DOI: 10.1016/j.ijbiomac.2026.151680

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