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Article

The mechanism of autocatalytic activation of plant-type L-asparaginases.

The Journal of biological chemistry - 9 May 2008

Michalska Karolina, Hernandez-Santoyo Alejandra, Jaskolski Mariusz

Abstract excerpt

Plant l-asparaginases and their bacterial homologs, such as EcAIII found in Escherichia coli, form a subgroup of the N-terminal nucleophile (Ntn)-hydrolase family. In common with all Ntn-hydrolases, they are expressed as inactive precursors that undergo activation in an autocatalytic manner. The maturation process involves intramolecular hydrolysis of a single peptide bond, leading to the formation of two...

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Identifiers

PMID: 18334484
DOI: 10.1074/jbc.M800746200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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