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Article

Identification of high affinity bioactive Salbutamol conformer directed against mutated (Thr164Ile) beta 2 adrenergic receptor.

Current topics in medicinal chemistry - 1 Jan 2015

Bandaru Srinivas, Tiwari Geet, Akka Jyothy, Marri Vijaya Kumar, Alvala Mallika, Gutlapalli Venkata Ravi, Nayarisseri Anuraj, Mundluru Hema Prasad

Abstract excerpt

Salbutamol forms an important and widely administered β2 agonist prescribed in the symptomatic treatment of bronchial asthma. Unfortunately, a subset of patients show refractoriness to it owing to ADRB2 gene variant (rs 1800888). The variant substitutes Thr to Ile at the position 164 in the β2 adrenergic receptor leading to sub-optimal binding of agonists. The present study aims to associate the Salbutamol...

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Share to Administration, Inhalation
Share to Adrenergic beta-2 Receptor Agonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Albuterol

Share to Bronchodilator Agents

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Share to High-Throughput Screening Assays

Share to Receptors, Adrenergic, beta-2

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Source

Identifiers

PMID: 25579570
DOI: 10.2174/1568026615666150112113040

Genes

ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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