Article
Identification of Small Molecule as a High Affinity β2 Agonist Promiscuously Targeting Wild and Mutated (Thr164Ile) β 2 Adrenergic Receptor in the Treatment of Bronchial Asthma.
Current pharmaceutical design - 1 Jan 2016
Bandaru Srinivas, Alvala Mallika, Akka Jyothy, Sagurthi Someshwar Rao, Nayarisseri Anuraj, Singh Sanjeev Kumar, Mundluru Hema Prasad
Abstract excerpt
BACKGROUND: A subset of asthmatics shows refractoriness to Salbutamol owing to ADRB2 gene C.T polymorphism (rs 1800888) that substitutes Thr to Ile at the position 164 in the β2 adrenergic receptor leading to sub-optimal binding of Salbutamol. The present study aims to associate the Salbutamol (200 mcg) refractoriness with the polymorphism and select the best existing agonist with optimal binding affinity against...
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