Article
Association of Beta 2 adrenergic receptor (Thr164Ile) polymorphism with Salbutamol refractoriness in severe asthmatics from Indian population.
Gene - 30 Oct 2016
Bandaru Srinivas, Tarigopula Pramod, Akka Jyothy, Marri Vijaya Kumar, Kattamuri Ramesh Kumar, Nayarisseri Anuraj, Mangalarapu Madhavi, Vinukonda Swetha, Mundluru Hema Prasad, Sagurthi Someswar Rao
Abstract excerpt
BACKGROUND: Thr164Ile polymorphism in the ADRB2 gene encoding β2 adrenergic receptor (β2AR) has its functional consequence in declining ligand-receptor interactions and depressed coupling of β2AR to adenylcyclase. In the present study, we sought to evaluate the possible association of Thr164Ile polymorphism with asthma susceptibility, pharmacogenetic response to Salbutamol and varying degrees of severity....
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