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Article

Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven response

28 Mar 2000

Abstract excerpt

OBJECTIVE: To better understand B-cell activation in MS by analyzing the immunoglobulin (Ig)G heavy chain variable region (VH) repertoire found in MS brains and comparing it with brain VH sequences in individuals with subacute sclerosing panencephalitis (SSPE)--a chronic encephalitis produced by measles virus (MV)-and characterized by an antigen-driven oligoclonal IgG response to MV antigens. BACKGROUND: The...

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PMID: 10746589
DOI: 10.1212/wnl.54.6.1227

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