Article

Aerobic exercise-induced up-regulation of HIF-1α ameliorates heart failure by regulating MCT1 and MPC1 expression

2024-01-01

Abstract excerpt

<title>Abstract</title> <p>Background The terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metabolic disturbances in cardiomyocytes. Based on high sensitivity to hypoxia, the failing heart activates cellular metabolic adaptation to balance energy demand by accumulating hypoxia-inducible factor-1α (HIF-1α). Furthermore, monocarboxylic acid transporte...

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Literature Corpus work: abd29542-d965-5392-a753-c56a788a339d
DOI: 10.21203/rs.3.rs-3814786/v1

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