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Article

Cooperating oncogenic events in murine mammary tumorigenesis: assessment of ErbB2, mutant p53, and mouse mammary tumor virus.

Experimental and molecular pathology - 1 Jun 2001

Zelazny E, Li B, Anagnostopoulos A M, Coleman A, Perkins A S

Abstract excerpt

We are investigating cooperating genetic events in the genesis of breast cancer, using the mouse as a model system. We have shown cooperativity between a mutant allele of p53 (p53-172H) and overexpressed ErbB2 in mammary tumorigenesis in transgenic mice. We are now performing additional crosses to further examine oncogene cooperativity with ErbB2 and p53-172H. We attempted to test the dominant oncogenic potential...

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Share to Epithelial Cells
Share to Genes, erbB-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

Share to Mammary Tumor Virus, Mouse

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Share to Receptor, ErbB-2

Source

Identifiers

PMID: 11417997
DOI: 10.1006/exmp.2001.2357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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