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Article

Mutant p53 gain of function induces HER2 over-expression in cancer cells

3 Jul 2018

Abstract excerpt

BACKGROUND: HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of sporadic breast cancer of the HER2 subtypes, besides a high percentage of HER2-amplifying tumors carry germline mutations of p53. The mechanisms responsible for the acquisition of oncogenic functions...

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PMID: 29970031
DOI: 10.1186/s12885-018-4613-1

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