Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells.

Oncotarget - 24 Jan 2017

Li Dun, Marchenko Natalia D

Abstract excerpt

Mutations in the p53 tumor suppressor gene are the most prevalent genetic events in human Her2-positive breast cancer and are associated with poor prognosis and survival. Human clinical data and our in vitro and in vivo studies strongly suggest potent oncogenic cooperation between mutant p53 and Her2 (ErbB2). Yet, the translational significance of mutant p53 in Her2 positive breast cancer, especially with respect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Lapatinib
Share to Protein Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteolysis

Share to Quinazolines

Share to Receptor, ErbB-2

Share to Tumor Suppressor Protein p53

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 27791982
DOI: 10.18632/oncotarget.12878
PMCID: PMC5351592

Genes

HSF1
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells.PMID 27791982Read ↗

Attenuation of p53 mutant as an approach for treatment Her2-positive cancerSemantic proximity Read ↗

A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53Semantic proximity Read ↗

Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer TherapySemantic proximity Read ↗

An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.Semantic proximity Read ↗

A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.Semantic proximity Read ↗

Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 Mutations and PHLDA1.Semantic proximity Read ↗

Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis.Semantic proximity Read ↗

MST4 plays dual roles in lung adenocarcinoma by regulating homeostasis of wild-type and mutant p53 protein.Semantic proximity Read ↗

ERBB2-Mediated Transcriptional Up-regulation of the α5β1 Integrin Fibronectin Receptor Promotes Tumor Cell Survival Under Adverse ConditionsSemantic proximity Read ↗

Role of Erbin in ErbB2-dependent breast tumor growth.Semantic proximity Read ↗

Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib.Semantic proximity Read ↗

Mechanisms of lapatinib resistance in HER2-driven breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.